1. Repositorio Institucional de la Universidad de Guanajuato
  2. Tesis
  3. Tesis de Posgrado
  4. CLE - Campus León. Tesis de Posgrado
  5. DCS - División de Ciencias de la Salud. Tesis de Posgrado
  6. Maestría en Investigación Clínica
Please use this identifier to cite or link to this item: http://repositorio.ugto.mx/handle/20.500.12059/373
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dc.rights.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0es_MX
dc.contributor.authorLissett Esther Martínez Magaña-
dc.contributor.authorCLARA ALBA BETANCOURT-
dc.creatorRAFAEL RODRIGUEZ CORTESes_MX
dc.date2017-01-
dc.date.accessioned2018-08-14T06:25:36Z-
dc.date.available2018-08-14T06:25:36Z-
dc.date.issued2017-01-
dc.identifier.urihttp://www.repositorio.ugto.mx/handle/20.500.12059/373-
dc.description.abstractEvaluar la utilidad de la HbA1c como predictor de la disfunción de las células B pancreáticas y la resistencia a insulina en pacientes sin diagnóstico previo de diabetes. Estudio de prueba diagnóstica en 455 sujetos voluntarios de 18 - 65 años sin diagnóstico previo de diabetes tipo 2 (DT2).es_MX
dc.language.isospaes_MX
dc.relationhttp://repositorio.ugto.mx/handle/20.500.12059/373-
dc.rightsinfo:eu-repo/semantics/openAccesses_MX
dc.subject.classificationCLE- Maestría en Investigación Clínicaes_MX
dc.titleUtilidad de la hemoglobina glucosilada A1c para predecir disfunción de células beta pancreáticas y resistencia a insulina en población mexicana sin diagnóstico previo de diabeteses_MX
dc.typeinfo:eu-repo/semantics/masterThesises_MX
dc.creator.idinfo:eu-repo/dai/mx/curp/ROCR861210HTCDRF05es_MX
dc.subject.ctiinfo:eu-repo/classification/cti/32es_MX
dc.subject.keywordsCiencias Médicases_MX
dc.subject.keywordsCiencias clínicases_MX
dc.contributor.roleanalistaes_MX
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_MX
dc.contributor.oneMaría de Lourdes Reyes Escogidoes_MX
dc.contributor.twoRODOLFO GUARDADO MENDOZAes_MX
dc.contributor.idoneinfo:eu-repo/dai/mx/curp/REEL730214MZSYSR07es_MX
dc.contributor.idoneinfo:eu-repo/dai/mx/cvu/161750-
dc.contributor.idtwoinfo:eu-repo/dai/mx/curp/GUMR740407HJCRND04es_MX
dc.contributor.roleonedirectores_MX
dc.contributor.roletwodirectores_MX
dc.contributor.rolethreeanalistaes_MX
dc.contributor.rolefouranalistaes_MX
dc.contributor.rolefiveanalistaes_MX
dc.contributor.rolesixanalistaes_MX
dc.publisher.universityUniversidad de Guanajuatoes_MX
dc.description.abstractEnglishTo assess the usefulness of HbA1c as a predictor of pancreatic B-cell dysfunction and insulin resistance in patients without prior diagnosis of diabetes. Diagnostic test study in 455 volunteer subjects aged 18-65 years without previous diagnosis of type 2 diabetes (DT2).es_MX
dc.description.abstractEnglishIntroduction: Several studies have related acute pancreatitis processes with obesity and high triglycerides levels. Objective: To assess the effect of metformin on the alterations in triglycerides and amylase serum levels caused by a high fructose, fat and cholesterol diet (HFFCD). Materials and methods: For 7 weeks, male New Zealand rabbits were subjected to HFFCD. The body weight variation was measured as well as amylase and triglycerides serum levels at the end of HFFCD. Three rabbits were treated with metformin (300mg/kg/día). Results: The HFFCD group showed a gain of 8.5 +/- 2.6 % in the body weight, as well as an increase of 20.6 +/- 6.7% and 29.6 +/- 4.7 % in the serum levels of amylase and triglycerides, respectively, compared to control. The two HFFCD rabbits were dead after two doses of metformin. Discussion-conclusion: The triglycerides levels observed in the HFFCD group, suggest an alteration in the pancreatic activity due to the establishment of an acute pancreatitis, which leads to an increase in amylase levels, facilitating the conditions that contribute to the development of other diseases related to obesity. We suspect a HFFCD and metformin associated acidosis as the cause of death.-
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